High severity intermediate · Fix: 5-10 min

RuntimeError

anthropic.RuntimeError

What this error means
The Anthropic async client raised a RuntimeError due to improper async usage or event loop conflicts during API calls.

Stack trace

traceback
Traceback (most recent call last):
  File "app.py", line 42, in <module>
    response = await client.messages.create(model="claude-3", messages=messages)
  File "/usr/local/lib/python3.10/site-packages/anthropic/client.py", line 210, in create
    raise RuntimeError("Event loop is closed or invalid")
RuntimeError: Event loop is closed or invalid
QUICK FIX
Wrap Anthropic async client calls inside async functions and run them with asyncio.run() to ensure a valid event loop.

Why it happens

This error occurs when the Anthropic async client is used improperly in an environment where the asyncio event loop is closed, missing, or conflicting. It often happens if the client is called outside an async function or if the event loop is prematurely closed or reused incorrectly.

Detection

Detect this error by wrapping async Anthropic client calls in try/except RuntimeError and logging the event loop state or error message before retrying or fixing the async context.

Causes & fixes

1

Calling async Anthropic client methods outside an async function or without awaiting

✓ Fix

Ensure all Anthropic async client calls are made inside async functions and are awaited properly.

2

Using the Anthropic async client in a synchronous context without an event loop

✓ Fix

Run the async client calls inside an asyncio event loop using asyncio.run() or an equivalent async runner.

3

Prematurely closing or reusing the asyncio event loop causing it to be invalid

✓ Fix

Avoid closing the event loop manually; let the runtime manage it or recreate a fresh event loop before client calls.

Code: broken vs fixed

Broken - triggers the error
python
from anthropic import Anthropic

client = Anthropic(api_key="sk-xxx")

messages = [{"role": "user", "content": "Hello"}]

# This line causes RuntimeError because it's called at top-level without async context
response = await client.messages.create(model="claude-3", messages=messages)
print(response)
Fixed - works correctly
python
import os
import asyncio
from anthropic import Anthropic

client = Anthropic(api_key=os.environ["ANTHROPIC_API_KEY"])

messages = [{"role": "user", "content": "Hello"}]

async def main():
    response = await client.messages.create(model="claude-3", messages=messages)  # Fixed: inside async function
    print(response)

asyncio.run(main())  # Fixed: runs async function with event loop
Moved the async client call inside an async function and used asyncio.run() to ensure a valid event loop, preventing RuntimeError.

Workaround

If you cannot refactor to async, run the async call synchronously by wrapping it with asyncio.run() or use an async-to-sync helper library to manage the event loop.

Prevention

Design your application to use async/await properly with the Anthropic client, avoid manual event loop management, and test async calls in isolated async contexts to prevent event loop errors.

Python 3.9+ · anthropic >=0.20.0 · tested on 0.20.x
Verified 2026-04
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